22, 2010, in the Journal of Clinical Investigation. Related StoriesNew antenna-like device makes breast cancer medical procedures less complicated for surgeonsViralytics enters into clinical trial collaboration agreement with MSDMD Anderson study reveals why chemotherapy medications not effective for most pancreatic cancer sufferers’We found that these drugs block the ‘tumor sponsor interactions’ bought at sites of metastasis, which is normally what reduces tumor development at these sites,’ said lead author Dan Theodorescu, MD, PhD, director of the University of Colorado Cancers Center and professor of surgery and pharmacology at the University of Colorado College of Medicine.A challenge for oral medicines, for example, is getting them to do some good before the body destroys them. A patient’s metabolism can do its job too well taking a drug out of circulation. Called first-pass metabolism, the liver breaks down a drug during its 1st trip circulating through the physical body. The result is doctors must make use of greater amounts of oral medicines to achieve the therapeutic effect. Bad reactions from the higher doses or the inconvenience from prolonged treatment cause many patients to stop taking their medicines.