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Although the study centered on whether or not it had been effective in getting rid of the mucus buildup, researchers say it doesn’t mean taking cold medicine could have no impact. It generally does not mean it won’t cause you to feel better, Rubin said. The study was payed for and requested by Mucinex. CBS News’ requests for touch upon the analysis from Mucinex weren’t immediately returned.. Cold medicine ingredient zero much better than placebo, study finds An active ingredient found in many over-the-counter chilly medicines is unlikely to obtain gone your phlegm, a new study has found. The research published in the May 2014 issue of the Respiratory Care journal discovered that Glyceryl Guaiacolate Ether , also called guaifenesin, provides no assistance in getting people with a cool to cough up the excess mucus.